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Propofol is widely used to sedate agitated patients in intensive care units However, it can cause a rare but fatal complication, propofol-related infusion syndrome ( PRIS ) The pathophysiology of PRIS is not clear, and there is no definitive diagnosis and treatment Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease Apr 30, 2024 · Propofol-related infusion syndrome ( PRIS ) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS Propofol-related Infusion Syndrome ( PRIS ) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of: 3 days ago · The Power Reactor Information System ( PRIS ), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide Propofol infusion syndrome ( PRIS ) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Forgot password? The Power Reactor Information System ( PRIS ), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide PRIS contains information on power reactors in operation, under construction, or those being decommissioned Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism

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